Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

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Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits.

Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain

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Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current medications have limitations and new approaches are needed, particularly given the current opioid crisis. There is some clinical evidence that the plant Cannabis sativa produces relief from neuropathic pain. This animal data suggests that cannabidiol and low dose nabiximols warrant consideration for clinical studies, at least as adjuvants to current drugs. Preclinical research is also required to identify other phytocannabinoids that have therapeutic potential.

Democrat Pete Buttigieg used marijuana ‘a handful of times’

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Pete Buttigieg, speaking to reporters after touring a legal pot dispensary in suburban Las Vegas, was asked about whether he’d ever used marijuana.
Perhaps some of the blame for this lies with the man who, a century ago, was probably the most famous economist in the world – Irving Fisher.

It was Fisher who notoriously claimed, in October 1929, the stock market had reached “a permanently high plateau”.

What prohibition’s failure means for the legalisation of cannabis

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Economists have a bit of an image problem. People think we shamelessly massage statistics, overconfidently make terrible predictions, and are no fun at drinks parties.

Perhaps some of the blame for this lies with the man who, a century ago, was probably the most famous economist in the world – Irving Fisher.

It was Fisher who notoriously claimed, in October 1929, the stock market had reached “a permanently high plateau”.

Medical Marijuana Research Shows Promise in Lessening Opioid Use & Abuse

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Medical marijuana shows early promise to lessen opioid use and potential abuse, suggests a systematic review of published studies being presented at the ANESTHESIOLOGY® 2019 annual meeting. However, much more rigorous scientific research must be done to determine if there truly are pain relief benefits to medical marijuana that can ease chronic pain and outweigh potential risks.

Potential of Cannabidiol for the Treatment of Viral Hepatitis

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Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none at the moment. Preliminary screening of cannabidiol (CBD) revealed that CBD is active against HCV but not against HBV in vitro. CBD inhibited HCV replication by 86.4% at a single concentration of 10 μM with EC50 of 3.163 μM in a dose-response assay. These findings suggest that CBD could be further developed and used therapeutically against HCV.