The use of medical grade cannabis in Italy for drug-resistant epilepsy: a case series

In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE who started therapy with MGC. Despite the small sample size and open-label nature of the data, we show that MGC may be successfully used to treat DRE. This is especially true when considering that no valid therapeutic option exists for these patients and that MGC was extremely well tolerated.

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials

Significant advances have increased our understanding of the molecular mechanisms of amyotrophic lateral sclerosis (ALS), yet this has not translated into any greatly effective therapies. It appears that a number of abnormal physiological processes occur simultaneously in this devastating disease. Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending life expectancy and substantially reducing the overall burden of the disease.

Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives

Neurodegenerative diseases are increasing in parallel to the lengthening of survival. The management of Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD-related disorders, and motor neuron diseases (MND), is mainly targeted to motor and cognitive impairment, with special care for vital functions such as breathing and feeding. Emerging evidences on the possible anti-nociceptive effects of cannabis or botulinum toxin might be available soon.

The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide. There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis has been successfully trialed as an effective treatment for managing epileptic symptoms, but whose mechanisms of action are largely unknown. Lately, there has been a focus on neuroinflammation as an important factor in the pathology of many epileptic disorders.

Relax, Willie Nelson Has Not Quit Weed

country legend Willie Nelson played two shows at San Antonio’s Majestic Theatre and gave an interview to local news station KSAT-TV about touring life and his career-long love affair with cannabis. In the chat, the 86-year-old musician revealed, “I have abused my lungs quite a bit in the past, so breathing is a little more difficult these days and I have to be careful.” Because of that, he’s given up smoking pot: “I don’t smoke anymore [to] take better care of myself,” he explained.

More evidence of cannabis efficacy in restless legs syndrome

Restless legs syndrome (RLS) is one of the most disabling and sometimes painful sensorimotor ailment of the nervous system that has only in recent years become more widely accepted as a clinical disorder with its own distinct features. Usually, symptoms respond well to dopamine agonists, anticonvulsants, or opiates, but still a subset of patients remains refractory to medical therapy and/or reports serious side effects.