HIV infection leads to blood-brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity.
Dr. Leo Hollister’s excellent article begins to address the need for better understanding of the effects of cannabis use on health. The last five years in the US have seen an increase in advocacy groups extolling the medicinal utility of cannabis.
Cannabis has been used medicinally to help manage pain for thousands of years – before prohibition began. However, the illegal status of cannabis in developed nations around the world – which coincided with the heights of scientific development and research – has meant that there is little clinical evidence of how medical cannabis can help with a whole range of conditions, including Fibromyalgia.
In a recent interview with the “TODDCast Podcast”, former SLAYER and current SUICIDAL TENDENCIES drummer Dave Lombardo was asked for his views on the legalization of marijuana.
In most cases, marijuana businesses must, like restaurants, limit themselves to takeout or delivery. Black-market dealers are also busy, but feel little need to abide by official orders.
Several substances besides tobacco are inhaled for recreational purposes, including marijuana, crack cocaine, amyl and butyl nitrites, heroin, methamphetamine, and phencyclidine.
For patients with chronic, non-cancer pain, traditional pain-relieving medications include opioids, which have shown benefits but are associated with increased risks of addiction and adverse effects. Medical cannabis has emerged as a treatment alternative for managing these patients and there has been a rise in the number of randomized clinical trials in recent years; therefore, a systematic review of the evidence was warranted.
As the global death toll continues to rise from the coronavirus pandemic and anxiety for Americans escalates along with the unemployment rate, operators of cannabis dispensaries across the country have reported that business is booming.
The endocannabinoid system (ECS) is a lipid signalling system, comprising of the endogenous cannabis-like ligands (endocannabinoids) anandamide (AEA) and 2-arachidonoylglycerol (2-AG), which derive from arachidonic acid.
In Michigan, marijuana sales have been declared an essential industry, meaning cannabis dispensaries have been allowed to stay open for business. But in Sheridan, Montcalm County, the green stuff is being given away for free to anyone who can prove they served in the military or were on Social Security disability.